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Mechanism of Action, Efficacy, and Safety of Propolis for the Management of Oral Mucositis : A Systematic Review
ABSTRAK ENGLISH
Mechanism of action, efficacy, and safety of propolis for the
management of oral mucositis: a systematic review
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Code CallNo Lokasi Ketersediaan IPM1 - 145 145 616.31 Ram M Jatinangor (Ilmu Penyakit Mulut (OM)) Tersedia namun tidak untuk dipinjamkan - No Loan -
Perpustakaan Fakultas Kedokteran GigiJudul Seri -No. Panggil 616.31 Ram MPenerbit FKG Unpad : FKG UNPAD JATINANGOR., 2022 Deskripsi Fisik -Bahasa EnglishISBN/ISSN 160110180005Klasifikasi 616.31Tipe Isi -Tipe Media -Tipe Pembawa -Edisi -Subyek Info Detil Spesifik -Pernyataan Tanggungjawab Anis Nur Ramdhiani (Author) -
ABSTRAK ENGLISH
Mechanism of action, efficacy, and safety of propolis for the
management of oral mucositis: a systematic review
Oral mucositis (OM) is an oral mucosal inflammation and complication of
chemotherapy and/or radiotherapy. One of the natural agents that has been widely
studied as an alternative therapy for OM was Propolis. This review aims to
analyze the effectiveness and safety of propolis and its mechanism of action in
preventing and treating OM through clinical study in human and animal models.
Articles searched using the keywords “Oral Mucositis” AND “Propolis”,
conducted through PubMed, ScienceDirect, and Cochrane Library databases. The
inclusion criteria were: Clinical Trial and Animal Study design; in English; full
paper available; published between 2016-2021; and high range of quality and
articles in line to the research topic. RoB-tools JADAD Oxford Quality Scoring
System and SYRCLE’s RoB tool was used for risk of bias determination. This
paper writing refers to PRISMA guidelines. In vivo studies and clinical trials have
shown that propolis can reduce OM Index scores in animals or OM grades in
patients. Propolis can also reduce the symptoms of inflammation in OM and
almost all articles stated that there were no side effects of propolis for oral
mucositis. In vivo studies showed that propolis was able to inhibit proinflammatory markers, hypoxia markers, MPO serum levels, and TNF-alpha
cytokines, but increased the expression of pS6, pAKT, NF-B, and GSH. Propolis
is effective and safe to use in patients receiving chemotherapy/radiotherapy to
prevent the severity and potential for OM therapy. The mechanism of action of
propolis in overcoming clinical symptoms of OM is as an anti-inflammatory,
antioxidant, and helps accelerate wound healing.
Keywords: Oral mucositis, Propolis, Chemotherapy, Radiotherapi -
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