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T172- Dimenhydrinate Orodispersible Tablets With A Novel Coprocessed Super Disintegrant of Microcrystalline Cellulose Isolated From Rami (Boehmeria nivea L Goud) (Nagina Belali; Dr.rer.nat., Anis Yohana Chaerunisaa, M.Si; Taofik Rusdiana, Ph.D)

Orally disintegrating tablets are prepared with superdisintegrants to disintegrate in mouth in matter of seconds, such disintegration is achieved by ...

  • CodeCallNoLokasiKetersediaan
    FFUP20190158T172Tersedia
  • Perpustakaan
    Fakultas Farmasi
    Judul Seri
    -
    No. Panggil
    T172
    Penerbit Fakultas Farmasi Universitas Padjadjaran : Jatinangor.,
    Deskripsi Fisik
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    Bahasa
    English
    ISBN/ISSN
    -
    Klasifikasi
    T172
    Tipe Isi
    -
    Tipe Media
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    Tipe Pembawa
    -
    Edisi
    -
    Subyek
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    Info Detil Spesifik
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    Pernyataan Tanggungjawab
  • Orally disintegrating tablets are prepared with superdisintegrants to disintegrate in mouth in matter of seconds, such disintegration is achieved by using superdisintegrants. Microcrystalline Cellulose isolated from Rami (MCC Rami) (Boehmeria nivea L. Gaud) has good disintegration properties, that can be further enhanced by co-processing it with crosspovidone (CP) that is an effective superdisintegrant. The aim of this study was to produce taste masked dimenhydrinate Orally disintegrating tablets with co-processed superdisintegrant ofMCC Rami with CP. MCC Rami was co-processed with CP by wet granulation in different ratios 15:3, 30:3, 30:7.5 given in mg respectively, to form co-processed superdisintegrant (SD).Dimenhydrinate was taste masked with 10% and 15% concentrations of Eudragit E100by Fluidized bed dryer (FBD). ODTs with dimenhydrinate powder andtaste masked dimenhydrinate microspheres were prepared with co-processed MCC Rami:CP as superdisintegrant.SD3 (30:7.5, MCC Rami:CP) was the best formula for co-processed SD with lowest disintegration time of 12 s in F6 dimenhydrinateODT and 20 s in F9taste masked dimenhydrinateODT. A significant difference in disintegration time of F1 79 s with MCC Rami (30 mg),F9 20s with SD3and F10 27 s where 7.5 mg of crosspovidone is used as SD was observed. Where disintegration time decreases from MCC Rami in F1 > CP in F10 > SD3 in F9 in a descending order, that reveals the effectiveness of co-processing in terms of decrease in disintegration time. Dimenhydrinate microspheres with 15% of Eudragit E 100 had masked the bitter taste of dimenhydrinate.MCC Rami has a potential to be used as a disintegrant in dispersible tablets as it has a disintegration time of 79 s that is in range of BP and USP limits fordispersible tablets and when co-processed with crosspovidone its disintegration properties are enhanced.
    KEYWORDS: Microcrystalline Cellulose, wet granulation, superdisintegrant, Boehmerianivea L. Gaud.

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