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Interleukin sebagai Biomarker pada Stomatitis Aftosa Rekuren (SAR) : Sebuah Tinjuan Pustaka Sistematik
Recurrent Aphthous Stomatitis (RAS) is a recurrent oral disease that causes pain and interferes with
daily oral function.1 The etiology of RAS ...
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Code CallNo Lokasi Ketersediaan IPM1 - 8 8 616.31 Dam I Jatinangor (Ilmu Penyakit Mulut (OM)) Tersedia namun tidak untuk dipinjamkan - No Loan -
Perpustakaan Fakultas Kedokteran GigiJudul Seri -No. Panggil 616.31 Dam IPenerbit FKG Unpad : FKG UNPAD JATINANGOR., 2021 Deskripsi Fisik -Bahasa IndonesiaISBN/ISSN 160110170014Klasifikasi 616.31Tipe Isi -Tipe Media -Tipe Pembawa -Edisi -Subyek Info Detil Spesifik -Pernyataan Tanggungjawab Indah Damayanti (Author) -
Recurrent Aphthous Stomatitis (RAS) is a recurrent oral disease that causes pain and interferes with
daily oral function.1 The etiology of RAS is not yet known, but its predisposition factors include
immunity disorders and genetic variations.2,3 Overproduction of interleukin (IL) and polymorphism
of the interleukin gene affect the recurrences and is found more in SAR patients.
4 This review aims
to describe the interleukins and interleukin gene polymorphisms related to and recommended as a
RAS biomarker. Articles were searched through PubMed, ScienceDirect, and Cochrane Library
databases, using the keywords of “Interleukin” AND “Recurrent Aphthous Stomatitis”. The Risk of
Bias Assessment tool for Non-randomized Studies (RoBANS) was used, and the writing of this
review refers to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA)
guidelines. A total of 8 articles met the criteria and showed a low risk of bias assessment. The level
of IL-2, IL-6, IL-8, and IL-18 in the acute clinical phase of RAS were higher than in the recovery
phase, but IL-10 levels showed decreased. IL-2, IL-6, IL-10 gene polymorphisms were found to be
more frequent in RAS patients compared to controls, while IL-12 gene polymorphisms were found to
be less associated with RAS pathogenesis. Interleukins at the proteomic level that recommended as a
pro-inflammatory biomarker are IL-2, IL-6, IL-8, IL-12, and IL-18, while an anti-inflammatory is
IL-10. Only IL-2 can be recommended as a biomarker at the genomic level, as other interleukins still
require other supporting data.
Keywords: Interleukin, recurrent aphthous stomatitis, biomarker, gene polymorphism. -
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