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Interleukin sebagai Biomarker pada Stomatitis Aftosa Rekuren (SAR) : Sebuah Tinjuan Pustaka Sistematik


Recurrent Aphthous Stomatitis (RAS) is a recurrent oral disease that causes pain and interferes with
daily oral function.1 The etiology of RAS ...

  • CodeCallNoLokasiKetersediaan
    IPM1 - 88 616.31 Dam IJatinangor (Ilmu Penyakit Mulut (OM))Tersedia namun tidak untuk dipinjamkan - No Loan
  • Perpustakaan
    Fakultas Kedokteran Gigi
    Judul Seri
    -
    No. Panggil
    616.31 Dam I
    Penerbit FKG Unpad : FKG UNPAD JATINANGOR.,
    Deskripsi Fisik
    -
    Bahasa
    Indonesia
    ISBN/ISSN
    160110170014
    Klasifikasi
    616.31
    Tipe Isi
    -
    Tipe Media
    -
    Tipe Pembawa
    -
    Edisi
    -
    Subyek
    Info Detil Spesifik
    -
    Pernyataan Tanggungjawab
  • Recurrent Aphthous Stomatitis (RAS) is a recurrent oral disease that causes pain and interferes with
    daily oral function.1 The etiology of RAS is not yet known, but its predisposition factors include
    immunity disorders and genetic variations.2,3 Overproduction of interleukin (IL) and polymorphism
    of the interleukin gene affect the recurrences and is found more in SAR patients.
    4 This review aims
    to describe the interleukins and interleukin gene polymorphisms related to and recommended as a
    RAS biomarker. Articles were searched through PubMed, ScienceDirect, and Cochrane Library
    databases, using the keywords of “Interleukin” AND “Recurrent Aphthous Stomatitis”. The Risk of
    Bias Assessment tool for Non-randomized Studies (RoBANS) was used, and the writing of this
    review refers to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA)
    guidelines. A total of 8 articles met the criteria and showed a low risk of bias assessment. The level
    of IL-2, IL-6, IL-8, and IL-18 in the acute clinical phase of RAS were higher than in the recovery
    phase, but IL-10 levels showed decreased. IL-2, IL-6, IL-10 gene polymorphisms were found to be
    more frequent in RAS patients compared to controls, while IL-12 gene polymorphisms were found to
    be less associated with RAS pathogenesis. Interleukins at the proteomic level that recommended as a
    pro-inflammatory biomarker are IL-2, IL-6, IL-8, IL-12, and IL-18, while an anti-inflammatory is
    IL-10. Only IL-2 can be recommended as a biomarker at the genomic level, as other interleukins still
    require other supporting data.
    Keywords: Interleukin, recurrent aphthous stomatitis, biomarker, gene polymorphism.
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