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The Potential Of Hyperbaric Oxygen Therapy In Enhancing Vegf : A Scoping Review (Overview On Angiogenesis Of Regenerative Endodontic Treatment)

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• Code	CallNo	Lokasi	Ketersediaan
  OB1 - 48	48 611 Wib T	Jatinangor (Oral Biologi)	Tersedia namun tidak untuk dipinjamkan - No Loan

• Perpustakaan	Fakultas Kedokteran Gigi
  Judul Seri	-
  No. Panggil	611 Wib T
  Penerbit	FKG Unpad : FKG UNPAD JATINANGOR., 2021
  Deskripsi Fisik	-
  Bahasa	Indonesia
  ISBN/ISSN	160110170081
  Klasifikasi	611
  Tipe Isi	-
  Tipe Media	-
  Tipe Pembawa	-
  Edisi	-
  Subyek	Angiogenesis Hyperbaric Oxygen Therapy (HBOT) pulp regeneration regenerative endodontic Vasculer endothelial growth factor (VEGF)
  Info Detil Spesifik	-
  Pernyataan Tanggungjawab	Dessy Pradyta Dian Wibayani (Author)

• Introduction: Hyperbaric oxygen therapy (HBOT) is known to have an effect in stimulating angiogenesis. Angiogenesis in regenerative endodontics is needed to improve blood supply, carry oxygen, nutrients, and stem cells which are useful for regenerating the pulp. Regenerative endodontics in mature permanent teeth has not been widely reported in studies because of the possible limitations in producing apical bleeding that capable to improve angiogenesis. This study aims to determine the effect of HBOT on angiogenesis by observing VEGF which is one of the most important proangiogenic growth factors. Methods: This study used a scoping review method with PRISMA-ScR analysis. Search for articles through PubMed, Cochrane Library, ScienceDirect, and Google Scholar with inclusion criterias are effects of hyperbaric oxygen therapy on angiogenesis, effects of hyperoxia on angiogenesis, VEGF expression on hyperoxia, effects hyperbaric oxygen therapy on VEGF expression, in Indonesian or English, and publication year limit from 2006 to 2021 and exclusion criterias are articles without full text and VEGF expression in normoxic and normobaric conditions. Results: Six articles reported there are significant increase of VEGF in HBOT group, one article reported an increase of VEGF but not significant, and one article reported no increase of VEGF in HBOT group. Conclusion: HBOT increases angiogenesis which is indicated by an increase of VEGF level. The analysis of articles show that angiogenesis at the molecular level of several tissues involves the same growth factor thus proving that HBOT also has a potential to increase angiogenesis that needed for regenerate the pulp in endodontic regenerative treatment. Keywords: Angiogenesis, Hyperbaric Oxygen Therapy (HBOT), pulp regeneration, regenerative endodontic, Vascular endothelial growth factor (VEGF).

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