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Correlation between Maternal Zinc Deficiency and Nonsyndromic Cleft Lip with or without Cleft Palate : A Rapid Review
Introduction: Nonsyndromic cleft lip and palate (NS CLP) is a congenital disorder
with the second-highest percentage in Indonesia. One of the ...
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Code CallNo Lokasi Ketersediaan Ped1 - 228 228 617.64 Mah C Jatinangor (Pedodonsia) Tersedia namun tidak untuk dipinjamkan - No Loan -
Perpustakaan Fakultas Kedokteran GigiJudul Seri -No. Panggil 617.64 Mah CPenerbit FKG Unpad : FKG UNPAD JATINANGOR., 2022 Deskripsi Fisik -Bahasa EnglishISBN/ISSN 160110180156Klasifikasi 617.64Tipe Isi -Tipe Media -Tipe Pembawa -Edisi -Subyek Info Detil Spesifik -Pernyataan Tanggungjawab Alanis Sakina Aghiya Mahanani (Author) -
Introduction: Nonsyndromic cleft lip and palate (NS CLP) is a congenital disorder
with the second-highest percentage in Indonesia. One of the factors that caused it
was micronutrient deficiency of the mother. Zinc deficiency during pregnancy is
suspected can increase the risk of babies with CLP. This rapid review aimed to
identify the correlation between maternal zinc deficiency and NS CLP. Methods:
This study was conducted using PRISMA via databases: PubMed, Google Scholar,
ScienceDirect, ProQuest, and Cochrane Library. All observational design study
which discusses zinc deficiency and CLP with publication year from 2007 – 2022
were included. Result: Nine articles were included in this rapid review: eight with
case-control design and one with cross-sectional design. Samples and methods for
assessing zinc levels vary in each article. Four articles reported a positive
correlation between zinc deficiency and CLP while the other five reported no
correlation. The risk of bias from all articles was low to moderate. Conclusion:
The included articles showed different findings on the correlation between maternal
zinc deficiency and NS CLP. A definitive correlation cannot be made due to the
varied samples and methods, and most articles had a moderate risk of bias.
Keyword : maternal zinc, zinc deficiency, nonsyndromic clef lip with cleft palate -
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