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The Practice of Medicinal Chemistry

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• Code	CallNo	Lokasi	Ketersediaan
  01021030500004			Tersedia

• Perpustakaan	Fakultas Farmasi
  Judul Seri	-
  No. Panggil	615.1-3 Wer P
  Penerbit	Elsevier : United Kingdom., 2006
  Deskripsi Fisik	Ed.2-Cet.1. xiv, 768 hal. Ilus. ; 28 cm Indeks. Hl
  Bahasa	Indonesia
  ISBN/ISSN	0-12-744481-5
  Klasifikasi	615.1-3 Wer P
  Tipe Isi	-
  Tipe Media	-
  Tipe Pembawa	-
  Edisi	NULL
  Subyek	Medicinal Chemistry Wermuth, Camille Georges
  Info Detil Spesifik	-
  Pernyataan Tanggungjawab	NULL

• This edition includes a concise introduction covering the definition and history of medicinal chemistry, the measurement of biological activities and the three main phases of drug activity. This is followed by detailed discussions on the discovery of new lead compounds including automated, high troughput screening techniques, combinatorial chemistry and the use of the internet, all of which serve to reduce pre-clinical development times nad thus the cost of drugs. Further chapters discuss the optimization of lead compounds in terms of potency, selectivity, and safety; the contribution of genomics; molecular biology and x-ray crystallization to drug discovery and development, including the design of peptidomimetic drugs; and the development of drug-delivery systems, including organ targeting and the preparation of pharmaceutically acceptable salts. The final section covers legal and economic aspects of drug discovery and production, including drug sources, good manufacturing practices, drug nomenclature, patent protection, social-economic implications and the future of the pharmaceutical industry.

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