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Mechanism of Action, Efficacy, and Safety of Propolis for the Management of Oral Mucositis : A Systematic Review

ABSTRAK ENGLISH
Mechanism of action, efficacy, and safety of propolis for the
management of oral mucositis: a systematic review

  • CodeCallNoLokasiKetersediaan
    IPM1 - 145145 616.31 Ram MJatinangor (Ilmu Penyakit Mulut (OM))Tersedia namun tidak untuk dipinjamkan - No Loan
  • Perpustakaan
    Fakultas Kedokteran Gigi
    Judul Seri
    -
    No. Panggil
    616.31 Ram M
    Penerbit FKG Unpad : FKG UNPAD JATINANGOR.,
    Deskripsi Fisik
    -
    Bahasa
    English
    ISBN/ISSN
    160110180005
    Klasifikasi
    616.31
    Tipe Isi
    -
    Tipe Media
    -
    Tipe Pembawa
    -
    Edisi
    -
    Subyek
    radiotherapy
    chemotherapy
    propolis
    Oral mucositis
    Info Detil Spesifik
    -
    Pernyataan Tanggungjawab
  • ABSTRAK ENGLISH
    Mechanism of action, efficacy, and safety of propolis for the
    management of oral mucositis: a systematic review
    Oral mucositis (OM) is an oral mucosal inflammation and complication of
    chemotherapy and/or radiotherapy. One of the natural agents that has been widely
    studied as an alternative therapy for OM was Propolis. This review aims to
    analyze the effectiveness and safety of propolis and its mechanism of action in
    preventing and treating OM through clinical study in human and animal models.
    Articles searched using the keywords “Oral Mucositis” AND “Propolis”,
    conducted through PubMed, ScienceDirect, and Cochrane Library databases. The
    inclusion criteria were: Clinical Trial and Animal Study design; in English; full
    paper available; published between 2016-2021; and high range of quality and
    articles in line to the research topic. RoB-tools JADAD Oxford Quality Scoring
    System and SYRCLE’s RoB tool was used for risk of bias determination. This
    paper writing refers to PRISMA guidelines. In vivo studies and clinical trials have
    shown that propolis can reduce OM Index scores in animals or OM grades in
    patients. Propolis can also reduce the symptoms of inflammation in OM and
    almost all articles stated that there were no side effects of propolis for oral
    mucositis. In vivo studies showed that propolis was able to inhibit proinflammatory markers, hypoxia markers, MPO serum levels, and TNF-alpha
    cytokines, but increased the expression of pS6, pAKT, NF-B, and GSH. Propolis
    is effective and safe to use in patients receiving chemotherapy/radiotherapy to
    prevent the severity and potential for OM therapy. The mechanism of action of
    propolis in overcoming clinical symptoms of OM is as an anti-inflammatory,
    antioxidant, and helps accelerate wound healing.
    Keywords: Oral mucositis, Propolis, Chemotherapy, Radiotherapi

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